Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dibutyltin dichloride → HCID 178499286, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dibutyltin dichloride | HCID 12688 | — |
| 반응물 | Phenylsilane | HCID 12752 | — |
| 반응물 | 3-Amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl ester | HCID 57795435 | — |
| 반응물 | 5-[1,2,4]Triazol-1-yl-heptan-2-one | HCID 67278637 | — |
| 생성물 | HCID 178499286 | HCID 178499286 | 81.4% |
반응 단계
Reductive amination of 3-amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl ester (0.630 g, 2.37 mmol) and 5-[1,2,4]triazol-1-yl-heptan-2-one (0.560 g, 3.39 mmol) was performed under the same conditions previously described (example 3, step I) using dibutyltin dichloride and phenylsilane to give 5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(trans-4-[1,2,4]triazol-1-yl-cyclohexylamino)-thiophene-2-carboxylic acid methyl ester (0.800 g, 64%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07569600B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-217bf567a3944959a8e51a5aa8c25382 |
| 출처 메모 | uspto-grants-2009_08 |