Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine

HRID 2099825노트

반응식

HRID 2099825 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[C:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][Cl:13])[CH:5]=[C:4]([CH3:10])[N:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 22504306(2-Chloro-6-methylpyridin-4-yl)methanol

생성물 1

HCID 216981672-Chloro-4-(chloromethyl)-6-methylpyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(2-Chloro-6-methylpyridin-4-yl)methanol (0.212 g, 1.35 mmol) and thionyl chloride (0.12 mL, 1.62 mmol) were combined in methylene chloride (4 mL) and stirred at room temperature for 4 h. The solvents were removed and the product dried under vacuum for several hours to afford 0.24 g (quant.) as a clear oil which was used without purification. Mass spec.: 176.0 (MH)+.

후처리

  1. customThe solvents were removed
  2. customthe product dried under vacuum for several hours
  3. customto afford 0.24 g (quant.) as a clear oil which
  4. customwas used without purification

출처 및 근거

ORD 기록
ord-2f6899c5c0574523b8288fa8836090b8
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569578B2

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