4-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide → 4-Amino-3-nitro-N-(3-pyridinylmethyl)benzenesulfonamide

HRID 2099848노트

반응식

HRID 2099848 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].[NH3:22].CO>>[NH2:22][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

참가 물질

3

반응물 2

HCID 28583054-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamideHCID 21705897Ammonia methanol

생성물 1

HCID 222851684-Amino-3-nitro-N-(3-pyridinylmethyl)benzenesulfonamide

반응 조건

온도
100 °C

실험 절차

Into a saturated ammonia-methanol solution (60 ml) was added 4-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide (2.77 g), followed by about 2 days of heating at 100° C. in a sealed tube. After the reaction, the solvent was evaporated under reduced pressure and the formed yellow crystals were collected by filtration and dried to obtain 4-amino-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide (2.51 g). Hereinafter, the compound of Reference Examples 26 was obtained similarly.

후처리

  1. customAfter the reaction
  2. customthe solvent was evaporated under reduced pressure
  3. filtrationthe formed yellow crystals were collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-80a05f61f7974e20b26e77a75147fa75
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569688B2

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