Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Hydroxymethyl)benzeneboronic acid → 3-Amino-4-(hydroxymethylphenyl)-6-bromophthalimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Hydroxymethyl)benzeneboronic acid | HCID 2734706 | — |
| 반응물 | 3-Amino-4-iodo-6-bromophthalimide | HCID 68488717 | — |
| 촉매 | Cuprous 2-thiophenecarboxylate | HCID 11194830 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Amino-4-(hydroxymethylphenyl)-6-bromophthalimide | HCID 68491204 | 64% |
| 생성물 | 3-Amino-4,6-di(4-hydroxymethylphenyl)phthalimide | HCID 68492902 | 29% |
반응 단계
In a similar manner to Step 2 of Example 2, 3-amino-4-iodo-6-bromophthalimide (100 mg, 0.273 mmol) was dissolved in THF (7 mL), and the solution was treated with 4-hydroxymethylphenylboronic acid (83 mg, 0.55 mmol), tetrakis(triphenylphosphine)palladium (25 mg, 0.022 mmol) and copper(I)thiophene-2-carboxylate (104 mg, 0.546 mmol), followed by purification by preparative thin-layer chromatography (chloroform/methanol=15/1) to obtain 3-amino-4-(hydroxymethylphenyl)-6-bromophthalimide (61 mg, yield 64%) and 3-amino-4,6-di(4-hydroxymethylphenyl)phthalimide (29 mg, yield 29%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-72bdee8320374be6a672ca3798ce76e8 |
| 출처 메모 | uspto-grants-2010_06 |