Ethyl 2-(4-(3,4-dimethoxybenzyloxy)-3-chlorobenzamido)-5-phenoxybenzoate → 2-(4-(3,4-Dimethoxybenzyloxy)-3-chlorobenzamido)-5-phenoxybenzoic acid

HRID 2099961노트

반응식

HRID 2099961 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][C:38]=1[O:39][CH3:40])[CH2:6][O:7][C:8]1[CH:34]=[CH:33][C:11]([C:12]([NH:14][C:15]2[CH:25]=[CH:24][C:23]([O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:22][C:16]=2[C:17]([O:19]CC)=[O:18])=[O:13])=[CH:10][C:9]=1[Cl:35]>C1COCC1.CO.O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][C:38]=1[O:39][CH3:40])[CH2:6][O:7][C:8]1[CH:34]=[CH:33][C:11]([C:12]([NH:14][C:15]2[CH:25]=[CH:24][C:23]([O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:22][C:16]=2[C:17]([OH:19])=[O:18])=[O:13])=[CH:10][C:9]=1[Cl:35]

참가 물질

5

반응물 1

HCID 57796889Ethyl 2-(4-(3,4-dimethoxybenzyloxy)-3-chlorobenzamido)-5-phenoxybenzoate

생성물 1

HCID 577968912-(4-(3,4-Dimethoxybenzyloxy)-3-chlorobenzamido)-5-phenoxybenzoic acid

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 1C (160 mg, 0.29 mmol) in THF (30 mL) and MeOH (10 mL) at 0° C. was treated with a solution of LiOH monohydrate (60 mg, 1.42 mmol) in water (10 mL). The resulting solution was stirred for 16 hours, and then concentrated to 10 mL. The resulting suspension was taken up in water (10 mL) and brought to pH 5 with 1 N HCl. The solution was extracted with EtOAc (4×25 mL), dried (Na2SO4), filtered and concentrated to afford the 1D as a white solid. (130 mg, 84%).

후처리

  1. concentrationconcentrated to 10 mL
  2. extractionThe solution was extracted with EtOAc (4×25 mL)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ff6af964ef47478a9bf4887ea6f908e9
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569725B2

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