Ethyl Acetate → Ethyl 2-amino-5-phenoxybenzoate

HRID 2099973노트

반응식

HRID 2099973 반응식
[N+:1]([C:4]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:11][C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7])([O-])=O.CCOC(C)=O>CO.[Pd]>[NH2:1][C:4]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:11][C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 57796884Ethyl 2-nitro-5-phenoxybenzoate

생성물 1

HCID 57796887Ethyl 2-amino-5-phenoxybenzoate수율 87%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 43A (3.35 g, 11.7 mmol) in MeOH (30 mL):EtOAc (30 mL) was degassed with argon for 30 minutes. The resulting solution was treated with 10% Pd/C (335 mg) and stirred under a hydrogen atmosphere for 2 hours. The reaction mixture was filtered through a pad of celite and concentrated to afford 43B (2.6 g, 87%).

후처리

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b00cdc49d6cb42249c2288e72e1949fa
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569725B2

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