Methanol → 4-Chloro-4'-methylsulfinylmethylbenzophenone

HRID 2100

반응식

HRID 2100 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][S:15][CH3:16])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.CO.I([O-])(=O)(=O)=[O:22].[Na+]>O>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][S:15]([CH3:16])=[O:22])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 196893654-Chloro-4'-methylthiomethylbenzophenoneHCID 23667635Sodium periodate

생성물 1

HCID 187798984-Chloro-4'-methylsulfinylmethylbenzophenone수율 93%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4-chloro-4'-methylthiomethylbenzophenone (4.2 g) was added to methanol (150 ml). Sodium periodate (3.6 g) dissolved in water (20 ml), was added to this solution, and the mixture was stirred for 16 hours at room temperature. The reaction mixture was concentrated, and water was added thereto. The mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (4.1 g, melting point: 116° to 118° C., yield: 93%).

후처리

  1. additionwas added to this solution
  2. concentrationThe reaction mixture was concentrated
  3. additionwater was added
  4. extractionThe mixture was extracted with ethyl acetate
  5. washThe ethyl acetate layer was washed with water
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationEthyl acetate was distilled off under reduced pressure
  8. washThe residual solid was washed with n-hexane

출처 및 근거

ORD 기록
ord-27d91eecd20e450da1b8e17f791b0eaa
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728699

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