2,6-Difluoropyridine-3-carboxylic acid → 2-[2-(3-Chloro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

반응식

F[C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[C:4]([F:11])[N:3]=1.Cl.[Cl:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][O:22][CH2:23][C:24]([NH2:26])=[NH:25])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[CH:15]=[C:16]([CH2:20][CH2:21][O:22][CH2:23][C:24]2[NH:26][C:8](=[O:10])[C:7]3[CH:6]=[CH:5][C:4]([F:11])=[N:3][C:2]=3[N:25]=2)[CH:17]=[CH:18][CH:19]=1

참가 물질

반응물 2

HCID 105830702,6-Difluoropyridine-3-carboxylic acid

HCID 67098848HCID 67098848, 화합물

생성물 1

HCID 1358991932-[2-(3-Chloro-phenyl)-ethoxymethyl]-7-fluoro-3H-pyrido[2,3-d]pyrimidin-4-one

실험 절차

The title compound was prepared in analogy to example 85 from 2,6-difluoropyridine-3-carboxylic acid and 2-[2-(3-chloro-phenyl)-ethoxy]-acetamidine hydrochloride (example 79.2). Light brown solid. MS: m/e=334.1 [M+H+].

출처 및 근거

ORD 기록: ord-cdef599c18f043b3bbf5de860d2e2b34
출처 데이터셋: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07572801B2

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