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Dimethylformamide → Ethyl 4-[ethyl(3-methylphenyl)amino]butanoate

HRID 2100642
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인쇄 미리보기

반응식

HRID 2100642 반응식
[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH2:6][CH2:7]Br)[CH3:2].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C.[CH2:21]([NH:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=1)[CH3:22]>C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH2:6][CH2:7][N:23]([CH2:21][CH3:22])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=1)[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 7603N-ethyl-3-methylanilineHCID 11430Potassium CarbonateHCID 76300Ethyl 4-bromobutyrate

생성물 1

HCID 66966695Ethyl 4-[ethyl(3-methylphenyl)amino]butanoate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
95 °C

실험 절차

4-Bromobutyric acid ethyl ester (17.1 ml), potassium carbonate (20.5 g), and DMF (80 ml) were added to N-ethyl-m-toluidine (8 g), and the mixture was stirred at 95° C. for 17 hours. The reaction mixture was diluted with ethyl acetate, washed with water, and dried over magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel chromatography (hexane-ethyl acetate) to give the title compound (14.1 g).

후처리

  1. washwashed with water
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated
  4. customthe residue was purified by silica gel chromatography (hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-a6d02ee545174970bed4a06579dfe9e9
출처 데이터셋
uspto-grants-2009_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07572815B2

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