HCID 68858098, 화합물 → HCID 57799727, 화합물

HRID 2100737노트

반응식

HRID 2100737 반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:17]=[CH:18][C:19]([OH:21])=[O:20])[CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH2:14][O:15][CH3:16].[H][H]>CCOC(C)=O.CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH2:14][O:15][CH3:16]

참가 물질

6

반응물 2

HCID 68858098HCID 68858098, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 57799727HCID 57799727, 화합물수율 78.5%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 3-[3,4-Bis-(2-methoxy-ethoxy)-phenyl]-acrylic acid (20 g, 67.5 mmol) in EtOAc (100 ml) and MeOH (100 ml) was added carefully 10% Pd/C (1.5 g), then the mixture was shaken in Parr apparatus for 5 hs under 30-40 psi of hydrogen. The solution was passed through a celite pad, and the filtrate was concentrated to give product (15 g, 78.5%). LC-MS: m/e 297 (M−1)

후처리

  1. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-24a71ca7ced44372bac9d20c1be78751
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572809B2

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