Thiophene-3-boronic acid → HCID 57799519, 화합물

HRID 2100905노트

반응식

HRID 2100905 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[C:16]([CH3:18])[NH:15][N:14]=2)[N:3]=1.[S:19]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20]1>>[CH3:18][C:16]1[NH:15][N:14]=[C:13]([NH:12][C:4]2[N:3]=[C:2]([C:21]3[CH:22]=[CH:23][S:19][CH:20]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:17]=1

참가 물질

3

반응물 2

HCID 581760Thiophene-3-boronic acidHCID 57799635(1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

생성물 1

HCID 57799519HCID 57799519, 화합물

실험 절차

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and thiophene-3-boronic acid to give (5-methyl-1H-pyrazol-3-yl)-(1-thiophen-3-yl-isoquinolin-3-yl)-amine. LC-MS m/e 307(MH+).

출처 및 근거

ORD 기록
ord-0681f236f30e44e28d044a70fe7e9174
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572809B2

반응 노트

불러오는 중…