Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Difluorophenylboronic acid → [1-(2,4-difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Difluorophenylboronic acid | HCID 2734334 | — |
| 반응물 | (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine | HCID 57799674 | — |
| 생성물 | [1-(2,4-difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine | HCID 23633788 | — |
반응 단계
Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and 2,4-difluoro-phenylboronic acid to give [1-(2,4-difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 367(MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07572809B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-2700f5a318184eccbd7cbd4d0936fd2f |
| 출처 메모 | uspto-grants-2009_08 |