Isopropanol → HCID 57799853, 화합물

반응식

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8](F)=[C:9]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=2)[CH:5]=[C:4]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:3]=1.[CH3:25][CH:26]([OH:28])[CH3:27]>>[CH:26]([O:28][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH:9]([CH3:10])[CH3:8])=[C:9]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=2)[CH:5]=[C:4]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:3]=1)([CH3:27])[CH3:25]

참가 물질

반응물 2

HCID 3776Isopropanol

HCID 57799490[1-Chloro-6-fluoro-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine

생성물 1

HCID 57799853HCID 57799853, 화합물

실험 절차

Similar procedure as described in example 10 was used, starting from [1-Chloro-6-fluoro-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine and 2-propanol to give [1,6-Diisopropoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 415(MH+).

출처 및 근거

ORD 기록: ord-71e007cdabc1467fb279762ba89bb92c
출처 데이터셋: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07572809B2

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