Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2101125생성일: 2026년 10월 27일
Acetic Acid → (7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine
https://huagongshe.com/reaction/2101125
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (1-Chloro-7-fluoro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine | HCID 57799484 | — |
| 생성물 | (7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine | HCID 57799513 | — |
반응 단계
NaH (155 mg) was added to a solution of ispropanol (500 mg) in DME (2 ml) and stirred for 1 hour. 1-Chloro-7-fluoro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (100 mg) (example 9B) was added to the mixture, and the mixture was heated at 180° C. for 30 minutes under microwave irradiation. The reaction mixture was acidified to PH=7 with acetic acid and purified by preparative LC-MS to give (7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 331 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07572809B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_08 |
|---|
| ORD ID | ord-0ac85877e82249508c88f51e0b824eab |
|---|
| 출처 메모 | uspto-grants-2009_08 |
|---|
