Sodium hydride → [1-Isopropoxy-6-methoxy-7-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine

참여 물질

역할	이름	HCID	투입량
반응물	Sodium hydride	HCID 24758	—
반응물	2-Morpholinoethanol	HCID 61163	—
반응물	(7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine	HCID 57799513	—
용매	Acetic Acid	HCID 176	—
생성물	[1-Isopropoxy-6-methoxy-7-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine	HCID 57799526	—

반응 조건

온도	180 °C

반응 단계

NaH (155 mg) was added to a solution of 2-Morpholin-4-yl-ethanol (2 ml) and stirred for 1 hour. (7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (100 mg) was added to the mixture, and the mixture was heated at 180° C. for 1 hour under microwave irradiation. The reaction mixture was acidified to PH=7 with acetic acid and purified by preparative LC-MS to give [1-Isopropoxy-6-methoxy-7-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine (28 mg). LC-MS: m/e 442(MH+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07572809B2
출처 데이터셋	uspto-grants-2009_08
ORD ID	ord-244937dffefa474c9910e9f54b65e208
출처 메모	uspto-grants-2009_08