1H-Pyrazol-3-amine, 5-methyl- → HCID 178486774, 화합물

HRID 2101138노트

반응식

HRID 2101138 반응식
[Cl:1][C:2]1[C:3]([CH2:15][C:16]#[N:17])=[C:4]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[C:5](O)=[O:6].[NH2:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=1>C(O)(=O)C>[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[C:4]2[C:3]=1[CH:15]=[C:16]([NH:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=1)[N:17]=[C:5]2[OH:6]

참가 물질

4

반응물 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 577996033-Chloro-2-cyanomethyl-4,5-dimethoxy-benzoic acid

생성물 1

HCID 178486774HCID 178486774, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Similar procedure as described in example 9B was used, starting from 3-Chloro-2-cyanomethyl-4,5-dimethoxy-benzoic acid, 3-amino-5-methylpyrazol and acetic acid to give 5-Chloro-6,7-dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol. LC-MS: m/e 335 (MH+).

출처 및 근거

ORD 기록
ord-a1524193587547f5980653257cf177f2
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572809B2

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