1,1'-Carbonyldiimidazole → 8-Bromo-7-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

HRID 2101300

반응식

HRID 2101300 반응식
[Br:1][C:2]1[C:3]([NH:15][NH2:16])=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1.[C:17](N1C=CN=C1)(N1C=CN=C1)=[O:18]>C1COCC1>[Br:1][C:2]1[C:3]2[N:4]([C:17](=[O:18])[NH:16][N:15]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 577994543-Bromo-4-(4-chlorophenyl)-2-hydrazinylpyridine

생성물 1

HCID 577994388-Bromo-7-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one수율 84.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

Crude 3-bromo-4-(4-chlorophenyl)-2-hydrazinylpyridine (7 g, 23 mmol) was dissolved in dry THF (100 mL), and the resulting solution was cooled to 0° C. To this was added 1,1′carbonyldiimidazole (18 g, 111 mmol). The reaction mixture was stirred at room temperature for 10 h. The solvent was evaporated under vacuum, and water (10 mL) was added, which caused solid desired product to precipitate. This was filtered, washed with water (2×25 mL), and dried to obtain the title compound as a yellow solid (6.3 g), which was used without further purification.

후처리

  1. customThe solvent was evaporated under vacuum, and water (10 mL)
  2. additionwas added
  3. customto precipitate
  4. filtrationThis was filtered
  5. washwashed with water (2×25 mL)
  6. customdried

출처 및 근거

ORD 기록
ord-f2374dc14b034ee3ace9ba8e8e5d09e1
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572808B2

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