5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-diethylamino-propyl)-amide → 3-[4-(3-Diethylaminopropylcarbamoyl)-3,5-dimethyl-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-4-carboxylic acid (3-chloro-4-methoxyphenyl)amide
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]([C:13]2[C:14]3[CH2:15][C:16](=[O:22])[NH:17][C:18]=3[CH:19]=[CH:20][CH:21]=2)=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH2:23]([N:25]([CH2:41][CH3:42])[CH2:26][CH2:27][CH2:28][NH:29][C:30]([C:32]1[C:36]([CH3:37])=[C:35]([CH:38]=O)[NH:34][C:33]=1[CH3:40])=[O:31])[CH3:24]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]([C:13]2[C:14]3[C:15](=[CH:38][C:35]4[NH:34][C:33]([CH3:40])=[C:32]([C:30](=[O:31])[NH:29][CH2:28][CH2:27][CH2:26][N:25]([CH2:41][CH3:42])[CH2:23][CH3:24])[C:36]=4[CH3:37])[C:16](=[O:22])[NH:17][C:18]=3[CH:19]=[CH:20][CH:21]=2)=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]참가 물질
3
반응물 2
생성물 1
실험 절차
2-Oxo-2,3-dihydro-1H-indole-4-carboxylic acid (3-chloro-4-methoxyphenyl)amide (1 g, 3.16 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-diethylaminopropyl)amide (1 g, 3.58 mmol) to give 1.7 g (85%) of the title compound as a yellow-orange solid. MS-EI m/z 578.2 [M+].