Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2101719생성일: 2026년 10월 26일
1-Aminopiperidine → N-(Piperidin-1-yl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide
https://huagongshe.com/reaction/2101719
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Aminopiperidine | HCID 16658 | — |
| 반응물 | Ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate | HCID 22066075 | — |
| 생성물 | N-(Piperidin-1-yl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide | HCID 10183243 | — |
반응 단계
A mixture of ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate (50 mg, 0.125 mmol) from Step D in neat 1-aminopiperidine (1 mL) was heated at 90° C. for 72 hr. Most of the amine was evaporated under a stream of nitrogen and the residue was purified by Prep TLC (2×1 mm, silica) (40% ethyl acetate in hexanes to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07572785B2 |
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| 출처 데이터셋 | uspto-grants-2009_08 |
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| ORD ID | ord-32a9b6ea237a4719b9ecba72c5ce1b06 |
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| 출처 메모 | uspto-grants-2009_08 |
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