Methanol → Methyl 3-cyclopropyl-3-(4-hydroxyphenyl)propanoate

HRID 2101782노트

반응식

HRID 2101782 반응식
[CH:1]1([CH:4]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[CH2:5][C:6]([OH:8])=[O:7])[CH2:3][CH2:2]1.[CH3:16]O>S(=O)(=O)(O)O.CCOC(C)=O>[CH:1]1([CH:4]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[CH2:5][C:6]([O:8][CH3:16])=[O:7])[CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 887MethanolHCID 576725253-Cyclopropyl-3-(4-hydroxyphenyl)propanoic acid

생성물 1

HCID 57672485Methyl 3-cyclopropyl-3-(4-hydroxyphenyl)propanoate수율 84%

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 21.3 (2.4 g, 12 mmol) in MeOH (25 mL) was added five drops of sulfuric acid. The mixture was stirred overnight at reflux, cooled to room temperature, diluted with EtOAc, washed with water and brine, dried over MgSO4, filtered, and concentrated. The crude product was chromatographed on silica gel (0-25% EtOAc/hexane) to afford 21.4 (2.2 g, 84%) as a colorless oil.

후처리

  1. temperatureat reflux
  2. washwashed with water and brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe crude product was chromatographed on silica gel (0-25% EtOAc/hexane)

출처 및 근거

ORD 기록
ord-a6c8a009d67146f9a794181615e75689
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572934B2

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