2-(Bromomethyl)-5-(trifluoromethyl)furan → 4-Chloro-2-(difluoromethyl)-1-{[5-(trifluoromethyl)-2-furanyl]methyl}-1H-indole-5-carbonitrile

HRID 2101854노트

반응식

HRID 2101854 반응식
[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.Br[CH2:17][C:18]1[O:19][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:22]=1>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH2:17][C:18]1[O:19][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 249859694-Chloro-2-(difluoromethyl)-1-{[5-(trifluoromethyl)-2-furanyl]methyl}-1H-indole-5-carbonitrile

실험 절차

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 2-(bromomethyl)-5-(trifluoromethyl)furan: MS (ESI) m/z 375 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-46ffe56c71044089a667cfee778f91b7
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572820B2

반응 노트

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