2-(Chloromethyl)-5-cyclopropyl-1,3,4-thiadiazole → 4-Chloro-1-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)methyl]-2-(difluoromethyl)-1H-indole-5-carbonitrile

HRID 2101856노트

반응식

HRID 2101856 반응식
[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.Cl[CH2:17][C:18]1[S:19][C:20]([CH:23]2[CH2:25][CH2:24]2)=[N:21][N:22]=1>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH2:17][C:18]1[S:19][C:20]([CH:23]2[CH2:25][CH2:24]2)=[N:21][N:22]=1

참가 물질

3

반응물 2

HCID 27576792-(Chloromethyl)-5-cyclopropyl-1,3,4-thiadiazoleHCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 249859714-Chloro-1-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)methyl]-2-(difluoromethyl)-1H-indole-5-carbonitrile

실험 절차

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 2-(chloromethyl)-5-cyclopropyl-1,3,4-thiadiazole: MS (ESI) m/z 365 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-5e2d19453a814bc5ad0a18979d58364d
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572820B2

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