2,2,2-Trifluoroethyl trifluoromethanesulfonate → 4-Chloro-5-(methyloxy)-1-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)-1H-benzimidazole

HRID 2102018노트

반응식

HRID 2102018 반응식
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:14])([F:13])[F:12])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH3:16].O([CH2:25][C:26]([F:29])([F:28])[F:27])S(C(F)(F)F)(=O)=O>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:12])([F:13])[F:14])[N:7]([CH2:25][C:26]([F:29])([F:28])[F:27])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH3:16]

참가 물질

3

반응물 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 578002944-Chloro-5-(methyloxy)-2-(trifluoromethyl)-1H-benzimidazole

생성물 1

HCID 578001464-Chloro-5-(methyloxy)-1-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)-1H-benzimidazole

실험 절차

Synthesized as described in Example 195D from 4-chloro-5-(methyloxy)-2-(trifluoromethyl)-1H-benzimidazole and trifluoroethyl triflate: MS (ESI) m/z 333 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-a4ccb780993b4814a1bcc99bb62da58b
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572820B2

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