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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2102126생성일: 2026년 10월 25일

4-(Chloromethyl)-2-(2-chlorophenyl)-1,3-thiazole → 1-{[2-(2-Chlorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102126

반응식

참여 물질

역할이름HCID투입량
반응물4-(Chloromethyl)-2-(2-chlorophenyl)-1,3-thiazoleHCID 2063595—
반응물2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
생성물1-{[2-(2-Chlorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67407473—

반응 단계

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 4-(chloromethyl)-2-(2-chlorophenyl)-1,3-thiazole: 1H NMR (400 MHz, CDCl3) δ 8.17 (m, 1H), 7.58 (d, J=8.3 Hz, 1H), 7.49 (m, 2H), 7.36 (m, 2H), 6.79 (s, 1H), 6.65 (s, 1H), 5.51 (s, 2H), 2.58 (s, 3H); MS (ES) m/z 432 (M+1) and 434 (M+1, isotope).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07572820B2
출처 데이터셋uspto-grants-2009_08
ORD IDord-f30ca3a184964c63bb020a4d2a8582ad
출처 메모uspto-grants-2009_08