Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Chloro-2-methylpropan-2-ol → 1-(2-Hydroxy-2-methylpropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Chloro-2-methylpropan-2-ol | HCID 68409 | — |
| 반응물 | 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 53309346 | — |
| 생성물 | 1-(2-Hydroxy-2-methylpropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67405604 | — |
반응 단계
Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 1-chloro-2-methyl-2-propanol: 1H NMR (400 MHz, CDCl3) δ 7.66 (d, J=8.5 Hz, 1H), 7.46 (d, J=8.5 Hz, 1H), 6.60 (s, 1H), 4.12 (s, 2H), 2.52 (s, 3H), 1.30 (s, 6H); MS (ES) m/z 297 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07572820B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-0f435fc62277422a936568c5e892a9c3 |
| 출처 메모 | uspto-grants-2009_08 |