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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Methanesulfonyl chloride → 2-[3-({[5-(5-Chloro-2-fluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}thio)-5-(2-thienyl)-4H-1,2,4-triazol-4-yl]ethyl methanesulfonate

HRID 2102289
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인쇄 미리보기

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HRID 2102289 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:28])=[C:6]([C:8]2[O:12][N:11]=[C:10]([CH2:13][S:14][C:15]3[N:19]([CH2:20][CH2:21][OH:22])[C:18]([C:23]4[S:24][CH:25]=[CH:26][CH:27]=4)=[N:17][N:16]=3)[N:9]=2)[CH:7]=1.[CH3:29][S:30](Cl)(=[O:32])=[O:31]>CN(C=O)C.N1C=CC=CC=1>[CH3:29][S:30]([O:22][CH2:21][CH2:20][N:19]1[C:18]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[N:17][N:16]=[C:15]1[S:14][CH2:13][C:10]1[N:9]=[C:8]([C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[F:28])[O:12][N:11]=1)(=[O:32])=[O:31]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 670708392-{3-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-5-thiophen-2-yl-[1,2,4]triazol-4-yl}-ethanol

생성물 1

HCID 866025852-[3-({[5-(5-Chloro-2-fluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}thio)-5-(2-thienyl)-4H-1,2,4-triazol-4-yl]ethyl methanesulfonate

시약·촉매·용매 2

HCID 1049Pyridine용매
HCID 6228
Dimethylformamide
용매

실험 절차

To a solution of 2-[3-({[5-(5-chloro-2-fluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}thio)-5-(2-thienyl)-4H-1,2,4-triazol-4-yl]ethanol in a mixture of DMF (1 ml) and pyridine (0.5 ml) was added methanesulfonyl chloride (20 uL). The mixture was stirred at r.t. for 24 h before poured onto water (10 ml). The crude product was filtered off and purified by chromatography on silica gel using 0-5% MeOH in DCM as eluent to give 43 mg of the title compound, which was used directly in the next step.

후처리

  1. additionbefore poured onto water (10 ml)
  2. filtrationThe crude product was filtered off
  3. custompurified by chromatography on silica gel using 0-5% MeOH in DCM as eluent

출처 및 근거

ORD 기록
ord-f9e3072143fa4ec48ea881121e9d2af8
출처 데이터셋
uspto-grants-2009_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07576077B2

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