HCID 23079541, 화합물 → 3-Benzyloxy-5-bromo-4-formyl-1-isopropyl-1H-pyrazole

HRID 2102334노트

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HRID 2102334 반응식
[CH2:1]([O:8][C:9]1[C:13]([CH2:14][OH:15])=[C:12]([Br:16])[N:11]([CH:17]([CH3:19])[CH3:18])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[C:13]([CH:14]=[O:15])=[C:12]([Br:16])[N:11]([CH:17]([CH3:19])[CH3:18])[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 23079541HCID 23079541, 화합물

생성물 1

HCID 230795443-Benzyloxy-5-bromo-4-formyl-1-isopropyl-1H-pyrazole수율 90.6%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

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온도
50 °C

실험 절차

3-Benzyloxy-5-bromo-4-hydroxymethyl-1-isopropyl-1H-pyrazole (3.0 g) was dissolved in dichloromethane (30 mL), and manganese dioxide (4 g) was added to the stirred solution at room temperature. The mixture was stirred at 50° C. for 1 hour. After the insoluble material was removed by filtration, the filtrate was concentrated under reduced pressure to give the title compound (2.7 g).

후처리

  1. customAfter the insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4c59d53826b045b981c7eea6d1564bd5
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576063B2

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