Triethylamine → 918525-01-6

HRID 2102739노트

반응식

HRID 2102739 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6](C(O)=O)=[CH:5][N:4]=1.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:19])C=CC=CC=1.C([N:31]([CH2:34]C)CC)C>C1(C)C=CC=CC=1>[N:31]([C:6]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[N:4][CH:5]=1)=[C:34]=[O:19]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 5924996-Methoxynicotinic acid

생성물 1

HCID 14599989918525-01-6

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

To a suspension of 6-methoxy-nicotinic acid (0.459 g, 3 mmol) (Matrix) in toluene (15 mL) was added diphenylphosphoryl azide (0.958 g, 3.5 mmol) (Aldrich), followed by the addition of triethylamine (0.35 g, 3.6 mmol) (Aldrich). The mixture was stirred at room temperature for 30 minutes and the mixture became clear. Then the mixture was heated at 80° C. for 2 hours. The mixture was cooling down to room temperature to give crude 5-isocyanato-2-methoxy-pyridine as 0.2 M solution of toluene and used for the next step without further purification.

후처리

  1. temperatureThen the mixture was heated at 80° C. for 2 hours
  2. temperatureThe mixture was cooling down to room temperature

출처 및 근거

ORD 기록
ord-1be6e55c0ce84a2594c09722f7cd59d3
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576082B2

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