Isopropanol → HCID 45117314, 화합물
반응식
[CH3:1][C:2]([CH3:14])([CH3:13])[C:3]#[C:4][C:5]1[N:10]=[CH:9]C(C#N)=[CH:7][N:6]=1.[OH-:15].[K+].[CH:17]([OH:20])([CH3:19])C>O>[CH3:1][C:2]([CH3:14])([CH3:13])[C:3]#[C:4][C:5]1[N:10]=[CH:9][C:19]([C:17]([OH:20])=[O:15])=[CH:7][N:6]=1참가 물질
5
실험 절차
A mixture 2-(3,3-dimethylbut-1-ynyl)pyrimidine-5-carbonitrile (1.0 g, 0.005 mol) and potassium hydroxide (2.8 g, 0.05 mol) in isopropanol (40 mL) and water (10 mL) was heated at reflux for three hours. The mixture was allowed to cool to room temperature and concentrated under vacuum. Water (200 mL) was added and the mixture was cooled to 0° C., then conc. HCl was added until a pH of 6 was obtained. The resulting off-white precipitate was collected by filtration and washed with water to give the product as a solid. m/z=205 (M+1).
후처리
- temperatureat reflux for three hours
- concentrationconcentrated under vacuum
- additionWater (200 mL) was added
- temperaturethe mixture was cooled to 0° C.
- additionconc. HCl was added until a pH of 6
- customwas obtained
- filtrationThe resulting off-white precipitate was collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-61ba0ab9033d45c8814379103ca02c56
- 출처 데이터셋
- uspto-grants-2009_08
- 특허 번호
- US07576099B2
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