HCID 68703275, 화합물 → (7-Aminoquinolin-3-yl)methanol

HRID 2102962노트

반응식

HRID 2102962 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[N:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[C:8]([NH:13]C(=O)OCC1C=CC=CC=1)[CH:7]=2>[Pd].CO>[NH2:13][C:8]1[CH:7]=[C:6]2[C:11]([CH:12]=[C:3]([CH2:2][OH:1])[CH:4]=[N:5]2)=[CH:10][CH:9]=1

참가 물질

4

반응물 1

HCID 68703275HCID 68703275, 화합물

생성물 1

HCID 59020657(7-Aminoquinolin-3-yl)methanol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of benzyl 3-(hydroxymethyl)quinolin-7-ylcarbamate (480 mg, 0.0016 mol), 10% Pd-C (50 mg), and MeOH (50 mL) was stirred under H2 (1 atm) for 1 h. The catalyst was filtered-off and the filtrate was concentrated to give the product as a yellow solid. LC-MS: 0.34 min, 175.1 (M+1).

후처리

  1. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-e762c4d1547747cf8c266e8ca536ca4e
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576099B2

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