Boron tribromide → 5',7'-dimethyl-1'-(quinolin-2-ylmethyl)-3',4'-dihydro-1'H-spiro[cyclobutane-1,2'-quinolin]-6'-ol

6′-Methoxy-5′,7′-dimethyl-1′-(quinolin-2-ylmethyl)-3′,4′-dihydro-1′H-spiro[cyclobutane-1,2′-quinoline] (250 mg) was dissolved in CH2Cl2 (10 mL). At 0° C., 2.5 mL of BBr3 (2 mL, 1M solution in CH2Cl2) was added to the flask. The mixture was stirred at 0° C. for 20 minutes and then at room temperature for 30 minutes. After removing the solvent and BBr3, the reaction was quenched by adding into it water. The aqueous solution was then extracted with ethyl acetate (3×20 mL). The organic layer was combined, dried over Na2SO4 and evaporated. The residue was purified by column chromatography (silicagel, 12% ethyl acetate/hexane), giving 5′,7′-dimethyl-1′-(quinolin-2-ylmethyl)-3′,4′-dihydro-1′H-spiro[cyclobutane-1,2′-quinolin]-6′-ol as a dark yellow solid (26 mg). 1H-NMR (300 MHz, CD3OD) δ=8.10 (m, 2H); 7.72-7.92 (m, 2H); 7.74 (m, 2H); 6.00 (s, 1H); 4.83 (s, 2H); 2.76 (s, 6H); 2.32 (m, 2H); 2.07 (s, 5H); 2.00 (s, 3H); 1.94 (m, 2H); 1.72 (m, 2H) ppm. MS: (m/z)=359 (100, M+H+)

1. waitat room temperature for 30 minutes
2. customAfter removing the solvent and BBr3
3. customthe reaction was quenched
4. additionby adding into it water
5. extractionThe aqueous solution was then extracted with ethyl acetate (3×20 mL)
6. dry with materialdried over Na2SO4
7. customevaporated
8. customThe residue was purified by column chromatography (silicagel, 12% ethyl acetate/hexane)

ORD 기록

ord-324d50014f7149eab7a4d8b4d63425d9

출처 데이터셋

uspto-grants-2009_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07576094B2