Sodium Iodide → 4-[3-(4-Propoxypiperidin-1-yl)propyl]-4H-benzo[1,4]oxazin-3-one

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Iodide	HCID 5238	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Propoxypiperidine	HCID 11492037	—
반응물	4-(3-chloropropyl)-2H-1,4-benzoxazin-3(4H)-one	HCID 23345150	—
용매	Ethylacetate heptane	HCID 21899848	—
생성물	4-[3-(4-Propoxypiperidin-1-yl)propyl]-4H-benzo[1,4]oxazin-3-one	HCID 10125833	76.2%

반응 단계

4-(3-Chloropropyl)-4H-benzo[1,4]oxazin-3-one (81MF08) (0.13 g, 0.58 mmol), K2CO3 (0.16 g, 1.15 mmol), NaI (0.17 g, 1.15 mmol) and 4-propoxypiperidine (0.089 g, 0.60 mmol) were mixed according to GP12. CC (SiO2; Heptane/EtOAc 4:1-4) gave the title compound (81(81MF08KS)) (0.147 g, 76%). 1H NMR (CDCl3) δ7.11-7.08 (m, 1H), 7.01-6.94 (m, 3H), 4.55 (s, 2H), 3.96 (t, J=7.2 Hz, 2H), 3.37 (t, J=6.8 Hz, 2H), 3.28-3.21 (m, 1H), 2.74-2.69 (m, 2H), 2.36 (t, J=7.2 Hz, 2H), 2.10-2.03 (m, 2H), 1.90-1.77 (m, 4H), 1.61-1.51 (m, 4H), 0.90 (t, J=7.2 Hz, 3H); 13C NMR (CDCl3) δ 164.3, 145.4, 128.7, 123.8, 122.8, 117.1, 115.1, 75.1, 69.6, 67.7, 55.5, 51.5, 39.6, 31.6, 24.9, 23.4, 10.7.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07576100B2
출처 데이터셋	uspto-grants-2009_08
ORD ID	ord-7273e7ea98774ffb8731c2d0f1d9638b
출처 메모	uspto-grants-2009_08