m-Chloroperbenzoic acid → 4-Trifluoromethyl-2-picoline-N-oxide
반응식
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1.ClC1C=CC=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:11])[F:10])[CH:5]=[CH:4][N+:3]=1[O-:20]참가 물질
4
실험 절차
To a solution of 2-methyl-4-(trifluoromethyl)pyridine (3.9 g, 24 mmol) in methylene chloride (50 mL) was added m-chloroperbenzoic acid (7.0 g, 31 mmol). After being stirred at room temperature overnight, the solution was washed with 50 mL of 1 N NaOH. The water phase was back-extracted with methylene chloride. The combined organic phases were dried over Na2SO4 and concentrated under vacuum to give the title compound. MS (M+H) 178.1.
후처리
- washthe solution was washed with 50 mL of 1 N NaOH
- extractionThe water phase was back-extracted with methylene chloride
- dry with materialThe combined organic phases were dried over Na2SO4
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-017604c2ca07434f86a150d1e967a373
- 출처 데이터셋
- uspto-grants-2009_08
- 특허 번호
- US07576089B2
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