1,8-Diiodooctane → 5-(8-(3H-1,2,3-triazol-4-ylthio)octylthio)-1H-1,2,3-triazole

HRID 2103942노트

반응식

HRID 2103942 반응식
[SH:1][C:2]1[NH:6][N:5]=[N:4][CH:3]=1.I[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]I>C(O)C>[N:4]1[CH:3]=[C:2]([S:1][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][S:1][C:2]2[NH:6][N:5]=[N:4][CH:3]=2)[NH:6][N:5]=1

참가 물질

4

반응물 2

HCID 906051,8-DiiodooctaneHCID 178527741HCID 178527741, 화합물2회

생성물 1

HCID 1784209285-(8-(3H-1,2,3-triazol-4-ylthio)octylthio)-1H-1,2,3-triazole수율 42%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

20 mmole of 5-mercapto-1H-1,2,3-triazole (sodium salt) was dissolved in 20 ml of ethanol in stirring. 10 mmole of 1,8-diiodooctane was added dropwise to the solution of 5-mercapto-1H-1,2,3-triazole (sodium salt), and stirred overnight. After the solvent was evaporated in vacuum, the residual was washed with 50 ml pure H2O for three times, and then with 50 ml hexane for 3 times. At last, the residual was dried in oven at 60° C. for 24 hours. 1.30 g product was obtained as white solid. Yield: 42%. 1H NMR (DMSO): δ (ppm) 7.88 (2H, s), 2.86 (4H, t, JH-H=7.14), 1.50 (4H, m), and 1.20-1.31 (8H, m).

후처리

  1. stirringstirred overnight
  2. customAfter the solvent was evaporated in vacuum
  3. washthe residual was washed with 50 ml pure H2O for three times
  4. customAt last, the residual was dried in oven at 60° C. for 24 hours

출처 및 근거

ORD 기록
ord-2fee72b930914d4face73da053944f0d
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576165B2

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