Isopropanol → HCID 11567771, 화합물

HRID 2104162노트

반응식

HRID 2104162 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=O.[F:18][C:19]([F:27])([F:26])[C:20](=[O:25])[CH2:21][C:22](=O)[CH3:23].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[Br:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:22]([CH3:23])[C:21]([C:20](=[O:25])[C:19]([F:27])([F:26])[F:18])=[C:9]2[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 1359860(2-Amino-5-bromophenyl)(4-fluorophenyl)methanone

생성물 1

HCID 11567771HCID 11567771, 화합물수율 80%

시약·촉매·용매 1

HCID 21899848Ethylacetate heptane용매

실험 절차

The title compound was prepared from (2-Amino-5-bromo-phenyl)-(4-fluoro-phenyl)-methanone [example A2] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 80%; MS: m/z=411/413 (M).

출처 및 근거

ORD 기록
ord-bd66588853bb48649329f174650ca4bd
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576217B2

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