Trifluoroacetic acid → 2-{6-[1-Ethyl-3-(4-trifluoromethoxyphenyl)ureido]-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid

HRID 2104265노트

반응식

HRID 2104265 반응식
C([O:5][C:6](=[O:40])[C:7]([S:10][C:11]1[C:20](OC)=[CH:19][C:18]2[CH2:17][CH:16]([N:23]([CH2:38][CH3:39])[C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=3)=[O:25])[CH2:15][CH2:14][C:13]=2[CH:12]=1)([CH3:9])[CH3:8])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:38]([N:23]([CH:16]1[CH2:15][CH2:14][C:13]2[CH:12]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:40])=[O:5])[CH:20]=[CH:19][C:18]=2[CH2:17]1)[C:24]([NH:26][C:27]1[CH:28]=[CH:29][C:30]([O:33][C:34]([F:37])([F:35])[F:36])=[CH:31][CH:32]=1)=[O:25])[CH3:39]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86601316HCID 86601316, 화합물

생성물 1

HCID 102552732-{6-[1-Ethyl-3-(4-trifluoromethoxyphenyl)ureido]-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 2-{6-[1-ethyl-3-(4-trifluoromethoxyphenyl)ureido]-3-methoxy-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid tert butyl ester (0.02 g; 0.03 mmol) dissolved in CH2Cl2 (1.5 mL) was added TFA (1.5 mL) and the reaction mixture was stirred at room temperature for 1.5 h. The solvent was removed under reduced pressure and the residue was purified by reverse-phase semi-prep HPLC eluting with a MeCN—H2O gradient to yield 2-{6-[1ethyl-3-(4-trifluoromethoxyphenyl)ureido]-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid as a white solid.

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified by reverse-phase semi-prep HPLC
  3. washeluting with a MeCN—H2O gradient

출처 및 근거

ORD 기록
ord-49bd0cea88484ce482fece0a6ccef0ea
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576238B2

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