Methanol → Methyl 3-methoxy-2-(methoxymethyl)propanoate

HRID 2104367노트

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HRID 2104367 반응식
[CH3:1][O-:2].[Na+].[CH3:4][O:5][C:6](=[O:11])[C:7]([CH2:9]Br)=[CH2:8].[CH3:12][OH:13]>C(OCC)C>[CH3:4][O:5][C:6](=[O:11])[CH:7]([CH2:9][O:13][CH3:12])[CH2:8][O:2][CH3:1]

참가 물질

5

반응물 3

HCID 887MethanolHCID 5210932-Propenoic acid, 2-(bromomethyl)-, methyl esterHCID 10942334Sodium Methoxide

생성물 1

HCID 22934772Methyl 3-methoxy-2-(methoxymethyl)propanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Sodium methoxide (1.21 g) was added to a solution of 2-(bromomethyl)acrylic acid methyl ester (1.0 mL) in methanol (10 mL), and the mixture was heated under reflux for 26 hours. The reaction mixture was cooled, and was diluted with diethyl ether. The precipitate was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate hexane=1:4), to thereby give the title compound (726 mg).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 26 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe precipitate was filtered off
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customThe residue was purified by silica gel column chromatography (ethyl acetate hexane=1:4)

출처 및 근거

ORD 기록
ord-16046a5f93d547d2b4805e75044ddccc
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576135B2

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