Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylsilane → 2-Chloro-4-ethyl-1-fluorobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylsilane | HCID 12052 | — |
| 반응물 | 3'-Chloro-4'-fluoroacetophenone | HCID 520422 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | 2-Chloro-4-ethyl-1-fluorobenzene | HCID 18711878 | 28.3% |
반응 단계
To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07576098B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-e628bb131f7d41c080af62910a34c143 |
| 출처 메모 | uspto-grants-2009_08 |