1-Methyl-3-phenyl-1H-1,2,4-triazole → (5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol

참여 물질

역할	이름	HCID	투입량
반응물	1-Methyl-3-phenyl-1H-1,2,4-triazole	HCID 10877408	—
반응물	(3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol	HCID 57803786	—
반응물	5-Ethyl-2-fluorobenzaldehyde	HCID 57803803	—
생성물	(5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol	HCID 57803805	—

반응 단계

According to the procedure for Intermediate 370.2, 1-methyl-3-phenyl-1H-1,2,4-triazole (105 mg, 0.66 mmol) and 5-ethyl-2-fluorobenzaldehyde (100 mg, 0.66 mmol) afforded 159 mg of Intermediate 385.1 as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 1.12 (t, J=7.70 Hz, 3H) 2.47 (q, J=7.42 Hz, 2H) 2.95 (d, J=9.05 Hz, 1H) 5.48 (d, J=9.29 Hz, 1H) 6.67 (dd, J=9.90, 8.44 Hz, 1H) 6.87-6.99 (m, 1H) 7.03 (dd, J=7.34, 2.20 Hz, 1H) 7.08-7.15 (m, 6H) 7.15-7.22 (m, 10H) 7.30-7.48 (m, 5H) 8.04-8.16 (m, 2H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07576098B2
출처 데이터셋	uspto-grants-2009_08
ORD ID	ord-4515e50cee2547a3a88efedbf277ae9c
출처 메모	uspto-grants-2009_08