5-Methoxy-2,3,3-trimethyl-3H-indole → 1-(3,5-dinitrobenzyl)-5-methoxy-2,3,3-trimethyl-3H-indolium iodide

HRID 2105101

반응식

HRID 2105101 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]2([CH3:14])[CH3:13].[N+:15]([C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([N+:26]([O-:28])=[O:27])[CH:25]=1)[CH2:21][I:22])([O-:17])=[O:16]>ClC1C=CC=CC=1Cl>[I-:22].[N+:15]([C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([N+:26]([O-:28])=[O:27])[CH:25]=1)[CH2:21][N+:8]1[C:9]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)[C:6]([CH3:14])([CH3:13])[C:7]=1[CH3:12])([O-:17])=[O:16]

참가 물질

4

반응물 2

HCID 110953925-Methoxy-2,3,3-trimethyl-3H-indoleHCID 226090731-(Iodomethyl)-3,5-dinitrobenzene

생성물 1

HCID 866375401-(3,5-dinitrobenzyl)-5-methoxy-2,3,3-trimethyl-3H-indolium iodide수율 52.5%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

반응 조건

온도
75 °C

실험 절차

To 5-methoxy-2,3,3-trimethyl-3H-indole (1.90 g) was added 3,5-dinitrobenzyl iodide (4.62 g) and 1,2-dichlorobenzene (10 ml). The mixture was heated at 75° C. for 3 hours, during which time an orange solid separated. The mixture was then cooled in an ice bath and the solid fraction collected by filtration; it was washed sequentially with dichlorobenzene and diethyl ether and dried under vacuum to give the product (2.62 g).

후처리

  1. customseparated
  2. temperatureThe mixture was then cooled in an ice bath
  3. filtrationthe solid fraction collected by filtration
  4. washit was washed sequentially with dichlorobenzene and diethyl ether
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-ed7bc65f4bc0467ca5bdcf6257ecb444
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579140B2

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