Methyl 5-aminopentanoate hydrochloride → HCID 69059993, 화합물

반응식

[NH:1]([C:8]1[N:13]=[C:12]([CH:14]=O)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([O:24]C)=O>>[NH:1]([C:8]1[N:13]=[C:12]([CH2:14][N:17]2[CH2:18][CH2:19][CH2:20][CH2:21][C:22]2=[O:24])[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 13672034Methyl 5-aminopentanoate hydrochloride

HCID 578078012-Anilinopyrimidine-4-carbaldehyde

생성물 1

HCID 69059993HCID 69059993, 화합물수율 51%

실험 절차

By an analogous process to Method 4, 2-anilinopyrimidin-4-carbaldehyde (Method 3; 3.24, 16.2 mmol) was treated with methyl 5-aminopentanoate hydrochloride (3.0 g, 17.9 mmol) to give the title compound (2.23 g, 51%) as a pale yellow solid. NMR: 1.85 (m, 4H), 2.5 (s, 2H), 3.4 (s, 2H), 4.58 (s, 2H), 6.63 (d, 1H), 7.05 (t, 1H), 7.3 (m, 3H), 7.62 (d, 2H), 8.34 (d, 1H); m/z 305.

출처 및 근거

ORD 기록: ord-ca782c86e6904f87a1363b17e4d0ae3a
출처 데이터셋: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07579344B2

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