Water → 2-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[-2-hydroxy-1-hydroxymethylethyl]amino]-7(8H)-pteridinone

HRID 2105158노트

반응식

HRID 2105158 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:11]1[N:20]=[C:19]([NH:21][CH:22]([CH2:25][OH:26])[CH2:23][OH:24])[C:18]2[N:17]=[CH:16][C:15](=[O:27])[NH:14][C:13]=2[N:12]=1.[OH2:28].[OH:29]OS([O-])=O.[K+]>C(#N)C>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10]([C:11]1[N:20]=[C:19]([NH:21][CH:22]([CH2:25][OH:26])[CH2:23][OH:24])[C:18]2[N:17]=[CH:16][C:15](=[O:27])[NH:14][C:13]=2[N:12]=1)(=[O:29])=[O:28]

참가 물질

5

반응물 3

HCID 962WaterHCID 225059782-[[(2,3-Difluorophenyl)methyl]thio]4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-7(8H)-pteridinoneHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 225059372-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[-2-hydroxy-1-hydroxymethylethyl]amino]-7(8H)-pteridinone

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-[[(2,3-Difluorophenyl)methyl]thio]-4-[[-2-hydroxy-1-hydroxymethylethyl]amino]-7(8H)-pteridinone (2.25 g) was stirred in acetonitrile (750 ml) and water (750 ml) with oxone (22.5 g) for 18 hrs. Acetonitrile was removed in vacuo to leave an aqueous suspension. The mixture was extracted into ethyl acetate. The combined extracts were washed with saturated sodium chloride solution, dried (MgSO4) and the solvent removed in vacuo to afford the subtitled compound (1.92 g).

후처리

  1. customAcetonitrile was removed in vacuo
  2. customto leave an aqueous suspension
  3. extractionThe mixture was extracted into ethyl acetate
  4. washThe combined extracts were washed with saturated sodium chloride solution
  5. dry with materialdried (MgSO4)
  6. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-2d8fe9402e314207a48ae185f8f324bb
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579342B2

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