(2-Fluorophenyl)methanethiol → 2-[[(2-Fluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

반응식

[F:1][C:2]1[C:7](F)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.FC1C=CC=CC=1CS>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1

참가 물질

반응물 2

HCID 522175(2-Fluorophenyl)methanethiol

HCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

생성물 1

HCID 688168852-[[(2-Fluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone수율 50.7%

실험 절차

The titled compound (0.089 g) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (0.20 g) and 2-fluorobenzylmercaptan (0.083 g).

출처 및 근거

ORD 기록: ord-296f41c11c91408e847c0ad1bbb3ae64
출처 데이터셋: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07579342B2

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