Thenyl mercaptan → 4-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[[(2-thienyl)methyl)thio]-7(8H)-pteridinone

반응식

F[C:2]1[C:7](F)=[CH:6]C=C[C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.[S:29]1C=CC=C1CS>>[OH:26][CH2:25][C@H:24]([NH:23][C:21]1[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=[C:13]([S:10][CH2:9][C:3]2[S:29][CH:6]=[CH:7][CH:2]=2)[N:22]=1)[CH3:27]

참가 물질

반응물 2

HCID 80408Thenyl mercaptan

HCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

생성물 1

HCID 688161344-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[[(2-thienyl)methyl)thio]-7(8H)-pteridinone수율 56.6%

실험 절차

The titled compound (0.076 g) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (0.20 g) and 2-thienylmethylmercaptan (0.050 g).

출처 및 근거

ORD 기록: ord-7351a331112e499eb71703af752f1a2c
출처 데이터셋: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07579342B2

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