4-chloroquinolin-3-amine → HCID 86625942, 화합물

HRID 2105453노트

반응식

HRID 2105453 반응식
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[Cl:12])=[N:9][CH:8]=[CH:7][CH:6]=2.[NH2:13][C:14]1[CH:15]=[N:16][C:17]2[C:22]([C:23]=1[Cl:24])=[CH:21][CH:20]=[CH:19][CH:18]=2>>[Cl:12][C:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][N:9]=2)[N:4]=[CH:3][C:2]=1[NH-:1].[Cl:24][C:23]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][C:14]=1[NH-:13]

참가 물질

4

반응물 2

HCID 8173324-chloroquinolin-3-amineHCID 666199614-Chloro-1,5-naphthyridin-3-amine

생성물 2

HCID 86625942HCID 86625942, 화합물HCID 86625943HCID 86625943, 화합물

실험 절차

In step (6) of Reaction Scheme II, a 3-amino-4-chloro[1,5]naphthyridine or 3-amino-4-chloroquinoline of Formula XXXI is reacted with an acyl halide of Formula R2C(O)Cl or R2C(O)Br to provide an N-(4-chloro[1,5]naphthyridin-3-yl)amide or N-(4-chloroquinolin-3-yl)amide of Formula XXXII. The reaction can be carried out using the method described in step (2) of Reaction Scheme I.

후처리

  1. customIn step (6) of Reaction Scheme II

출처 및 근거

ORD 기록
ord-fcc7b40f76cd47a79acff92a409068b7
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579359B2

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