Triethylamine → HCID 57447109, 화합물

HRID 2105459노트

반응식

HRID 2105459 반응식
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].C(N(CC)CC)C.[NH2:14][C:15]1[CH:16]=[N:17][C:18]2[C:23]([C:24]=1[Cl:25])=[CH:22][CH:21]=[CH:20][CH:19]=2>ClCCl>[Cl:25][C:24]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=[CH:16][C:15]=1[NH:14][C:1](=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 8855Butyryl chlorideHCID 8173324-chloroquinolin-3-amine

생성물 1

HCID 57447109HCID 57447109, 화합물수율 48.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Butyryl chloride (0.72 mL, 6.94 mmol, 1.2 eq.) and triethylamine (1.13 mL, 8.09 mmol, 1.4 eq) were added to a solution of 3-amino-4-chloroquinoline (1.03 g, 5.78 mmol, 1.0 eq) in anhydrous dichloromethane (25 mL). The reaction mixture was stirred at ambient temperature for 3 hours and then washed sequentially with saturated aqueous sodium bicarbonate and brine, dried over magnesium sulfate, and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel eluting with 3% methanol in dichloromethane) to provide 0.70 g of N-(4-chloroquinolin-3-yl)butyramide.

후처리

  1. washwashed sequentially with saturated aqueous sodium bicarbonate and brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe crude product was purified by column chromatography (silica gel eluting with 3% methanol in dichloromethane)

출처 및 근거

ORD 기록
ord-8e0bf9398d4840369802837136103411
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579359B2

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