Triethylamine → HCID 57447109, 화합물

HRID 2105462노트

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HRID 2105462 반응식
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].C(N(CC)CC)C.[NH2:14][C:15]1[CH:16]=[N:17][C:18]2[C:23]([C:24]=1[Cl:25])=[CH:22][CH:21]=[CH:20][CH:19]=2>ClCCl>[Cl:25][C:24]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=[CH:16][C:15]=1[NH:14][C:1](=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 8855Butyryl chlorideHCID 8173324-chloroquinolin-3-amine

생성물 1

HCID 57447109HCID 57447109, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Butyryl chloride (3.77 mL, 1.3 eq) and triethylamine (5.85 mL, 1.3 eq) were added sequentially to a chilled (0° C.) solution of 3-amino-4-chloroquinoline (5.0 g, 1.0 eq) in dichloromethane (100 mL). The reaction mixture was warmed to ambient temperature and then allowed to stir overnight. The reaction mixture was quenched with aqueous saturated sodium bicarbonate. The organic layer was separated and concentrated under reduced pressure to provide 6.5 g of N-(4-chloroquinolin-3-yl)butyramide.

후처리

  1. customThe reaction mixture was quenched with aqueous saturated sodium bicarbonate
  2. customThe organic layer was separated
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6e9f40f6bb0c408e8d1e99dead1287cb
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579359B2

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