Acetyl chloride → HCID 67506066, 화합물

HRID 2105467노트

반응식

HRID 2105467 반응식
[C:1](Cl)(=[O:3])[CH3:2].C(N(CC)CC)C.[NH2:12][C:13]1[CH:14]=[N:15][C:16]2[C:21]([C:22]=1[Cl:23])=[CH:20][CH:19]=[CH:18][CH:17]=2>ClCCl>[Cl:23][C:22]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[CH:14][C:13]=1[NH:12][C:1](=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 8173324-chloroquinolin-3-amine

생성물 1

HCID 67506066HCID 67506066, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Acetyl chloride (3.41 mL, 1.25 eq) and triethylamine (6.79 mL, 1.4 eq) were added sequentially to a solution of 3-amino-4-chloroquinoline (6.22 g, 1.0 eq) in dichloromethane (100 mL). The reaction mixture was stirred overnight and then washed sequentially with aqueous saturated sodium bicarbonate and brine, dried over magnesium sulfate, and then concentrated under reduced pressure to provide 6.68 g of N-(4-chloroquinolin-3-yl)acetamide.

후처리

  1. washwashed sequentially with aqueous saturated sodium bicarbonate and brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-88fb07731972457abaac6396ee3161b9
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579359B2

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