O-Methylhydroxylamine hydrochloride → HCID 67505819, 화합물

HRID 2105488노트

반응식

HRID 2105488 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[NH:12][C:13](=O)[CH:14]([CH3:16])[CH3:15].Cl.[CH3:19][O:20][NH2:21]>C(O)C>[CH:14]([C:13]1[N:21]([O:20][CH3:19])[C:2]2[C:11]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[N:5]=[CH:4][C:3]=2[N:12]=1)([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 67505834N-(4-chloroquinolin-3-yl)-2-methylpropanamide

생성물 1

HCID 67505819HCID 67505819, 화합물수율 84.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of N-(4-chloroquinolin-3-yl)-2-methylpropanamide (6.0 g, 24 mmol), O-methylhydroxylamine hydrochloride (2.5 g, 0.030 mol), and ethanol (75 mL) was heated at reflux for five hours, allowed to cool to room temperature, stirred overnight, and concentrated under reduced pressure. The residue was dissolved in dichloromethane (100 mL), and the solution was washed with saturated aqueous sodium carbonate (2×50 mL) dried over potassium carbonate, filtered, and concentrated under reduced pressure to provide 4.9 g of 2-isopropyl-1-methoxy-1H-imidazo[4,5-c]quinoline as a dark oil.

후처리

  1. temperatureat reflux for five hours
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residue was dissolved in dichloromethane (100 mL)
  4. washthe solution was washed with saturated aqueous sodium carbonate (2×50 mL)
  5. dry with materialdried over potassium carbonate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c64770c734a845a1aa82838330b66966
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579359B2

반응 노트

불러오는 중…