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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Malonic Acid → 3-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-acrylic acid

HRID 2105699
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인쇄 미리보기

반응식

HRID 2105699 반응식
O[CH:2]1[CH:9]2[CH2:10][C:5]3([C:11]4[NH:19][C:18]5[C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH3:23])[C:15](=[O:24])[N:14]([CH2:25][CH2:26][CH3:27])[C:13]=5[N:12]=4)[CH2:6][CH:7](O2)[CH:3]1O3.[C:28]([OH:34])(=[O:33])[CH2:29][C:30](O)=O.N1C=CC=C[CH:36]=1>N1CCCCC1>[O:24]=[C:15]1[N:14]([CH2:25][CH2:26][CH3:27])[C:13]2[N:12]=[C:11]([C:5]34[CH2:7][CH2:3][C:2]([CH:30]=[CH:29][C:28]([OH:34])=[O:33])([CH2:36][CH2:6]3)[CH2:9][CH2:10]4)[NH:19][C:18]=2[C:17](=[O:20])[N:16]1[CH2:21][CH2:22][CH3:23]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 867Malonic Acid2회HCID 1049PyridineHCID 187676238-(4-Hydroxy-2,6-dioxa-tricyclo [3.3.1.03.7]non-1-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione

생성물 1

HCID 670791013-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-acrylic acid

시약·촉매·용매 1

HCID 8082Piperidine촉매

실험 절차

4-(2,6-Dioxo-1,35-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane 1-carbaldehyde (XI, Example 9, 0.490 g, 1.32 mmol) is added to a mixture of malonic acid (0.275 g, 2.64 mmol), pyridine (2 ml), and piperidine (1 drop). The mixture is heated to 1000 for 16 hours. Four additional equivalents of malonic acid are added and heating continued for another 16 hours until consumption of aldehyde ceases, to give the title compound.

후처리

  1. temperatureThe mixture is heated to 1000 for 16 hours
  2. temperatureheating
  3. customcontinued for another 16 hours until consumption of aldehyde ceases

출처 및 근거

ORD 기록
ord-8f61e7dbee1345d9ad728ff8b28bfb6a
출처 데이터셋
uspto-grants-2009_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07579354B2

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